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A man who was badly hurt in a multi-vehicle pileup that shut down a section of a busy highway north of Toronto for several hours Tuesday has died of his injuries, police said Wednesday.

A motorcycle accident west of the city, meanwhile, claimed a second life early Wednesday morning.

And in a third traffic accident over the past 24 hours, a 14-year-old Toronto girl is in hospital with serious head injuries after being struck Tuesday evening by a Toronto Transit Commission bus in the city's east end.

A total of eight people were injured Tuesday morning, four seriously, when six vehicles including a motorcycle slammed into each other on Highway 404, which connects Toronto to Newmarket, Ont.

The incident began when a northbound car plowed through the median, became airborne and landed in the southbound lanes where a chain reaction swiftly ensued, provincial police said.

The driver of the northbound car was flown by air ambulance to hospital where he later succumbed to his injuries.

In Brampton Wednesday morning, a motorcyclist was riding along Queen Street near Airport Road around 7 a.m. when his motorbike clipped the side of a car and crashed into a roadside pole.

He was pronounced dead at the scene. Police were trying to establish why he lost control.

And also under scrutiny was an accident in Scarborough Tuesday night, around 9 p.m., when a teenager was crossing an intersection on a bicycle near Kingston Road and Lawrence Avenue East when a TTC bus struck her.

She sustained serious head injuries but is expected to survive, police said.

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