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Hardcover Fiction: April 16, 2022
| Rank | Title | Author | Publisher | List Price | Last week | Weeks on List |
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| 1 | The Diamond Eye | Kate Quinn | William Morrow | $24.99 | 1 | 3 |
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| 2 | It Ends with Us | Colleen Hoover | Atria Books | $22.99 | 2 | 21 |
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| 3 | Five Little Indians | Michelle Good | HarperCollins Canada | $22.99 | 3 | 3 |
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| 4 | The Paris Apartment | Lucy Foley | William Morrow | $24.99 | 4 | 7 |
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| 5 | Bluebird | Genevieve Graham | Simon & Schuster | $24.99 | - | 1 |
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| 6 | Lessons in Chemistry | Bonnie Garmus | Doubleday Canada | $24.95 | - | 1 |
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| 7 | Looking for Jane | Heather Marshall | Simon & Schuster | $24.99 | 8 | 6 |
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| 8 | Again, Rachel | Marian Keyes | Doubleday Canada | $24.00 | - | 1 |
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| 9 | Sea of Tranquility | Emily St. John Mandel | HarperCollins Canada | $29.99 | 7 | 2 |
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| 10 | The Long Weekend | Gilly Macmillan | William Morrow | $24.99 | 5 | 2 |
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Hardcover Non-Fiction: April 16, 2022
| Rank | Title | Author | Publisher | List Price | Last Week |
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| 1 | Atlas of the Heart | Brené Brown | Random House | $40.00 | 1 |
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| 2 | My Mother's War | Eva Taylor | Hanover Square Press | $21.99 | - |
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| 3 | Bittersweet | Susan Cain | Crown | $37.00 | - |
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| 4 | This Is Assisted Dying | Stefanie Green | Scribner | $24.99 | 3 |
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| 5 | The Betrayal of Anne Frank | Rosemary Sullivan | HarperCollins Canada | $34.99 | 6 |
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| 6 | Braiding Sweetgrass | Robin Wall Kimmerer | Milkweed Editions | $26.95 | 8 |
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| 7 | Run Towards the Danger | Sarah Polley | Hamish Hamilton | $35.00 | 5 |
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| 8 | Idiots | Laura Clery | Gallery Books | $36.00 | - |
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| 9 | Freezing Order | Bill Browder | Simon & Schuster | $36.99 | - |
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| 10 | The Storyteller | Dave Grohl | Dey Street Books | $36.99 | 10 |
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Paperback Fiction: April 16, 2022
| Rank | Title | Author | Publisher | List Price | Last Week |
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| 1 | Nine Lives | Danielle Steel | Delacorte Press | $11.99 | - |
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| 2 | 1st Case | James Patterson; Chris Tebbetts | Grand Central Publishing | $12.99 | 10 |
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| 3 | The Dark Hours | Michael Connelly | Little Brown | $22.99 | - |
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| 4 | The Seven Husbands of Evelyn Hugo | Taylor Jenkins Reid | Washington Square Press | $23.00 | 2 |
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| 5 | Verity | Colleen Hoover | Grand Central Publishing | $22.99 | 3 |
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| 6 | Ugly Love | Colleen Hoover | Atria Books | $22.99 | 4 |
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| 7 | Where the Crawdads Sing | Delia Owens | G.P. Putnam's Sons | $24.00 | 1 |
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| 8 | Ocean Prey | John Sandford | G.P. Putnam's Sons | $12.99 | - |
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| 9 | Hideaway | Nora Roberts | Saint Martin's Paperbacks | $12.99 | - |
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| 10 | Chainsaw Man, Vol. 10 | Tatsuki Fujimoto | Viz Media | $12.99 | 7 |
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Canadian Fiction: April 16, 2022
| Rank | Title | Author | Publisher | List Price | Last Week |
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| 1 | Five Little Indians | Michelle Good | HarperCollins Canada | $22.99 | 1 |
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| 2 | Bluebird | Genevieve Graham | Simon & Schuster | $24.99 | 8 |
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| 3 | Looking for Jane | Heather Marshall | Simon & Schuster | $24.99 | 3 |
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| 4 | Sea of Tranquility | Emily St. John Mandel | HarperCollins Canada | $29.99 | 2 |
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| 5 | Scarborough | Catherine Hernandez | Arsenal Pulp Press | $19.95 | 4 |
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| 6 | The Maid | Nita Prose | Viking | $24.95 | 5 |
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| 7 | Sari, Not Sari | Sonya Singh | Simon & Schuster | $22.00 | - |
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| 8 | Daughters of the Deer | Danielle Daniel | Random House Canada | $24.00 | 7 |
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| 9 | Her Last Goodbye | Rick Mofina | Mira | $12.99 | 9 |
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| 10 | The Circus Train | Amita Parikh | HarperCollins Canada | $24.99 | 6 |
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Canadian Non-Fiction: April 16, 2022
| Rank | Title | Author | Publisher | List Price | Last Week |
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| 1 | If I Knew Then | Jann Arden | Random House Canada | $19.95 | 1 |
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| 2 | This Is Assisted Dying | Stefanie Green | Scribner | $24.99 | 3 |
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| 3 | The Betrayal of Anne Frank | Rosemary Sullivan | HarperCollins Canada | $34.99 | 6 |
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| 4 | Run Towards the Danger | Sarah Polley | Hamish Hamilton | $35.00 | 5 |
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| 5 | Cat and Nat's Mom Secrets | Catherine Belknap; Natalie Telfer | Penguin Canada | $24.95 | 2 |
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| 6 | Life in the City of Dirty Water | Clayton Thomas-Muller | Allen Lane | $29.95 | 4 |
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| 7 | Finding the Mother Tree | Suzanne Simard | Allen Lane | $34.95 | 7 |
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| 8 | Stories I Might Regret Telling You | Martha Wainwright | Random House Canada | $34.95 | 10 |
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| 9 | 12 Rules for Life | Jordan B. Peterson | Random House Canada | $34.95 | - |
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| 10 | Burning Questions | Margaret Atwood | McClelland & Stewart | $36.95 | 8 |
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Juvenile: April 16, 2022
| Rank | Title | Author | Publisher | List Price | Last Week |
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| 1 | Wings Of Fire: The Flames of Hope | Tui T. Sutherland | Scholastic Press | $22.99 | 1 |
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| 2 | The Good Egg Presents: the Great Eggscape! | Jory John; Pete Oswald | HarperCollins Canada | $13.50 | 2 |
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| 3 | A Good Girl's Guide to Murder | Holly Jackson | Ember | $14.99 | 5 |
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| 4 | Pop-Up Peekaboo! Things That Go | DK | DK Children | $16.99 | - |
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| 5 | The Baby-Sitters's Club: Good-Bye Stacey, Good-Bye | Ann M. Martin; Gabriela Epstein | Graphix | $16.99 | 4 |
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| 6 | Cat Kid Comic Club Perspectives | Dav Pilkey | Graphix | $15.99 | 6 |
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| 7 | Realm of the Blue Mist | Amy Kim Kibuishi | Graphix | $16.99 | 7 |
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| 8 | Captain Underpants and the Sensational Saga of Sir Stinks-A-Lot: Color Edition (Captain Underpants #12) | Dav Pilkey | Scholastic | $15.99 | 3 |
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| 9 | Dog Man Unleashed | Dav Pilkey | Graphix | $15.99 | 9 |
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| 10 | Movie Novelization | Kate Howard | Scholastic | $8.99 | - |
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Self-Improvement: April 16, 2022
| Rank | Title | Author | Publisher | List Price | Last Week |
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| 1 | Be a Triangle | Lilly Singh | Doubleday Canada | $24.95 | - |
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| 2 | 101 Essays That Will Change the Way You Think | Brianna Wiest | Thought Catalog Books | $18.69 | 1 |
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| 3 | The Gifts of Imperfection | Brené Brown | Hazelden | $22.95 | 2 |
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| 4 | The Subtle Art Of Not Giving A F*ck | Mark Manson | HarperCollins Canada | $23.99 | 4 |
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| 5 | The Mountain Is You | Brianna Wiest | Thought Catalog Books | $22.43 | - |
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| 6 | Chicken Soup for the Soul: Believe in Angels | Amy Newmark | Chicken Soup for the Soul Publishing | $17.95 | - |
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| 7 | Life Force | Tony Robbins; Peter H. Diamandis; Robert Hariri | Simon & Schuster | $39.99 | 5 |
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| 8 | The Secret to Love, Health, and Money | Rhonda Byrne | Atria Books | $25.00 | 7 |
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| 9 | Super Gut | William Davis | Collins | $24.99 | 6 |
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| 10 | The Science of Nutrition | Rhiannon Lambert | DK | $39.00 | 3 |
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Romance/Erotica: April 16, 2022
| Rank | Title | Author | Publisher | List Price |
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| 1 | It Ends with Us | Colleen Hoover | Atria Books | $22.99 |
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| 2 | Again, Rachel | Marian Keyes | Doubleday Canada | $24.00 |
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| 3 | Ugly Love | Colleen Hoover | Atria Books | $22.99 |
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| 4 | Reminders of Him | Colleen Hoover | Montlake Romance | $22.95 |
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| 5 | The Love Hypothesis | Ali Hazelwood | Berkley | $22.00 |
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| 6 | Confess | Colleen Hoover | Atria Books | $22.99 |
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| 7 | Sari, Not Sari | Sonya Singh | Simon & Schuster | $22.00 |
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| 8 | The Spanish Love Deception | Elena Armas | Atria Books | $24.99 |
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| 9 | People We Meet on Vacation | Emily Henry | Berkley | $22.00 |
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| 10 | November 9 | Colleen Hoover | Atria Books | $22.99 |
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